Organ-specific features in clinical transplantation

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter reviews the current state of organ transplants, identifying the key outcomes, management strategies, and clinical challenges in various types of transplants. Transplant outcomes are outstanding and continue to improve in the short term; long-term patient and graft survivals are less so and remain a major concern. Importantly, the presence of metabolic, cholestatic diseases, and biliary atresia were associated with better outcomes than in liver malignancies. The chapter addresses pathways and potential opportunities for further investigation. Immunosuppressive therapy is required for transplant survival and is complicated by infection and malignancy. There are no specific tests that can predict the adequacy of immunosuppression. These therapies are remarkably effective against cellular rejection, but are less effective against antibody-mediated injury. Viral infections such as hepatitis C in the liver and BK polyoma virus in the kidney remain critical cause of late allograft failure.

Original languageEnglish (US)
Title of host publicationTransplant Immunology
Number of pages20
ISBN (Electronic)9781119072997
ISBN (Print)9780470658215
StatePublished - Sep 12 2015
Externally publishedYes


  • Allograft failure
  • Antibody-mediated injury
  • BK polyoma virus
  • Biliary atresia
  • Cellular rejection
  • Immunosuppressive therapy
  • Kidney transplantation
  • Liver malignancies
  • Organ transplants

ASJC Scopus subject areas

  • Medicine(all)


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