Organic Nanocarriers for Delivery and Targeting of Therapeutic Agents for Cancer Treatment

Yang Peng, Jitender Bariwal, Virender Kumar, Chalet Tan, Ram I. Mahato

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Nanocarriers have the capability to deliver a variety of drugs to disease sites. Different biological barriers prevent the successful delivery of nanoformulations to target sites, thereby limiting effective therapeutic response. Although numerous efforts have been made to design novel nanocarriers by incorporating various functionalities to get better therapies, most strategies have failed to translate drug delivery systems to the clinic. Impediments such as the incapability to hold drugs stably in nanocarriers during circulation, non-specific distribution, and inadequate delivery of therapeutic agents to target sites due to complex tumor microenvironment remain a challenge. Herein, different organic polymer and lipid-based nanocarriers and their encouraging therapeutic effectiveness to treat cancer are discussed. Recent development in multifunctional and stimuli sensitive nanocarriers is also highlighted. Finally, the challenges and innovative strategies to overcome various obstacles and limitations for their successful translation into the clinic are discussed.

Original languageEnglish (US)
Article number1900136
JournalAdvanced Therapeutics
Volume3
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • bioconjugation
  • biomaterials
  • cancer
  • liposomes
  • micelles
  • nanoparticles

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Pharmaceutical Science
  • Genetics(clinical)
  • Biochemistry, medical
  • Pharmacology (medical)

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