TY - JOUR
T1 - Organic phosphorus compounds - Nerve agents
AU - Barthold, Claudia L.
AU - Schier, Joshua G.
PY - 2005/10
Y1 - 2005/10
N2 - Nerve agents and OPP exposures must be recognized early and treated aggressively. Early airway and ventilatory support should occur in conjunction with antidotal therapy. Atropine should be titrated to control bronchorrhea. Initial pralidoxime therapy should be given as soon as possible in suspected OPC poisoning and ideally before aging occurs. Successful therapy for OPC poisoning may include repeat dosing of pralidoxime or a continuous infusion, depending on the situation. Diazepam should be given to control seizures that may occur in severe poisoning. Late complications depend on the type of OPC involved, and can include intermediate syndrome and peripheral neuropathy.
AB - Nerve agents and OPP exposures must be recognized early and treated aggressively. Early airway and ventilatory support should occur in conjunction with antidotal therapy. Atropine should be titrated to control bronchorrhea. Initial pralidoxime therapy should be given as soon as possible in suspected OPC poisoning and ideally before aging occurs. Successful therapy for OPC poisoning may include repeat dosing of pralidoxime or a continuous infusion, depending on the situation. Diazepam should be given to control seizures that may occur in severe poisoning. Late complications depend on the type of OPC involved, and can include intermediate syndrome and peripheral neuropathy.
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U2 - 10.1016/j.ccc.2005.05.010
DO - 10.1016/j.ccc.2005.05.010
M3 - Review article
C2 - 16168308
AN - SCOPUS:24944510819
VL - 21
SP - 673
EP - 689
JO - Critical Care Clinics
JF - Critical Care Clinics
SN - 0749-0704
IS - 4
ER -