Organic phosphorus compounds - Nerve agents

Claudia L. Barthold, Joshua G. Schier

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Nerve agents and OPP exposures must be recognized early and treated aggressively. Early airway and ventilatory support should occur in conjunction with antidotal therapy. Atropine should be titrated to control bronchorrhea. Initial pralidoxime therapy should be given as soon as possible in suspected OPC poisoning and ideally before aging occurs. Successful therapy for OPC poisoning may include repeat dosing of pralidoxime or a continuous infusion, depending on the situation. Diazepam should be given to control seizures that may occur in severe poisoning. Late complications depend on the type of OPC involved, and can include intermediate syndrome and peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)673-689
Number of pages17
JournalCritical Care Clinics
Issue number4
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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