Organic radical contrast agents for magnetic resonance imaging

Andrzej Rajca; Ying Wang; Michael Boska; Joseph T. Paletta; Arnon Olankitwanit; Michael A. Swanson; Deborah G. Mitchell; Sandra S. Eaton; Gareth R. Eaton; Suchada Rajca

doi:10.1021/ja3079829

Organic radical contrast agents for magnetic resonance imaging

Andrzej Rajca, Ying Wang, Michael Boska, Joseph T. Paletta, Arnon Olankitwanit, Michael A. Swanson, Deborah G. Mitchell, Sandra S. Eaton, Gareth R. Eaton, Suchada Rajca

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular ¹H water relaxivity (r₁) is ca. 5 mM^-1 s^-1. The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.

Original language	English (US)
Pages (from-to)	15724-15727
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	38
DOIs	https://doi.org/10.1021/ja3079829
State	Published - Sep 26 2012

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "Organic radical contrast agents for magnetic resonance imaging",

abstract = "We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular 1H water relaxivity (r1) is ca. 5 mM-1 s-1. The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.",

author = "Andrzej Rajca and Ying Wang and Michael Boska and Paletta, {Joseph T.} and Arnon Olankitwanit and Swanson, {Michael A.} and Mitchell, {Deborah G.} and Eaton, {Sandra S.} and Eaton, {Gareth R.} and Suchada Rajca",

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T1 - Organic radical contrast agents for magnetic resonance imaging

AU - Rajca, Andrzej

AU - Wang, Ying

AU - Boska, Michael

AU - Paletta, Joseph T.

AU - Olankitwanit, Arnon

AU - Swanson, Michael A.

AU - Mitchell, Deborah G.

AU - Eaton, Sandra S.

AU - Eaton, Gareth R.

AU - Rajca, Suchada

PY - 2012/9/26

Y1 - 2012/9/26

N2 - We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular 1H water relaxivity (r1) is ca. 5 mM-1 s-1. The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.

AB - We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular 1H water relaxivity (r1) is ca. 5 mM-1 s-1. The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

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ER -

Organic radical contrast agents for magnetic resonance imaging

Abstract

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