Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity

Siming Ma, Sang Goo Lee, Eun Bae Kim, Thomas J. Park, Andrei Seluanov, Vera Gorbunova, Rochelle Buffenstein, Javier Seravalli, Vadim N. Gladyshev

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Trace elements are essential to all mammals, but their distribution and utilization across species and organs remains unclear. Here, we examined 18 elements in the brain, heart, kidney, and liver of 26 mammalian species and report the elemental composition of these organs, the patterns of utilization across the species, and their correlation with body mass and longevity. Across the organs, we observed distinct distribution patterns for abundant elements, transition metals, and toxic elements. Some elements showed lineage-specific patterns, including reduced selenium utilization in African mole rats, and positive correlation between the number of selenocysteine residues in selenoprotein P and the selenium levels in liver and kidney across mammals. Body mass was linked positively to zinc levels, whereas species lifespan correlated positively with cadmium and negatively with selenium. This study provides insights into the variation of mammalian ionome by organ physiology, lineage specialization, body mass, and longevity.

Original languageEnglish (US)
Pages (from-to)1319-1326
Number of pages8
JournalCell Reports
Volume13
Issue number7
DOIs
StatePublished - Nov 17 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ma, S., Lee, S. G., Kim, E. B., Park, T. J., Seluanov, A., Gorbunova, V., Buffenstein, R., Seravalli, J., & Gladyshev, V. N. (2015). Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Reports, 13(7), 1319-1326. https://doi.org/10.1016/j.celrep.2015.10.014