@article{0627a1acac394d6bbe49e6bebcc82674,
title = "Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage",
abstract = "Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.",
author = "Marketa Kaucka and Tomas Zikmund and Marketa Tesarova and Daniel Gyllborg and Andreas Hellander and Josef Jaros and Jozef Kaiser and Julian Petersen and Bara Szarowska and Newton, {Phillip T.} and Vyacheslav Dyachuk and Lei Li and Hong Qian and Johansson, {Anne Sofie} and Yuji Mishina and Currie, {Joshua D.} and Tanaka, {Elly M.} and Alek Erickson and Andrew Dudley and Hjalmar Brismar and Paul Southam and Enrico Coen and Min Chen and Weinstein, {Lee S.} and Ales Hampl and Ernest Arenas and Chagin, {Andrei S.} and Kaj Fried and Igor Adameyko",
note = "Funding Information: European Molecular Biology Organization ALTF 216-2013 Marketa Kaucka Svenska S?llskapet f?r Medicinsk Forskning Marketa Kaucka National Institutes of Health Andreas Hellander Svenska Forskningsr?det For- mas Phillip T Newton Andrei S Chagin Kaj Fried Igor Adameyko Karolinska Institutet Phillip T Newton Andrei S Chagin Kaj Fried Igor Adameyko Bertil H?llstens Forskningsstif- telse Igor Adameyko ?ke Wiberg Stiftelse Igor Adameyko The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} Marketa Kaucka et al.",
year = "2017",
month = apr,
day = "17",
doi = "10.7554/eLife.25902",
language = "English (US)",
volume = "6",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}