Osteogenic Osteosarcoma

Jianning Tao, Yangjin Bae, Lisa L. Wang, Brendan Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Recent reviews on studies of familial syndromes, specimens, and cell lines derived from human osteosarcoma patients describe the genetic factors and signaling pathways that may be involved in several key processes in the pathogenesis, including initiation, progression, invasion, and metastasis. This chapter updates the current understanding of osteogenic osteosarcoma biology and reviews these recent findings from animal models. Osteosarcoma premalignant cells that initially acquire a mutation in different stages of osteoblast differentiation may transform or evolve into cancer stem cells (CSCs) or tumor initiating cells (TICs) through accumulation of additional genetic mutations during the tumor progression. The current challenge in application of targeted agents lies in the identification of biomarkers predictive of response/resistance and matching them with the particular histologic response of individual patients, hopefully resulting in successful translation of biology into clinical benefit.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Subtitle of host publicationEighth Edition
Number of pages9
ISBN (Electronic)9781118453926
ISBN (Print)9781118453889
StatePublished - Jul 19 2013
Externally publishedYes


  • Animal models
  • Biomarkers
  • Cancer stem cells (CSCs)
  • Mutations
  • Osteogenic osteosarcoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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