Abstract
Recent reviews on studies of familial syndromes, specimens, and cell lines derived from human osteosarcoma patients describe the genetic factors and signaling pathways that may be involved in several key processes in the pathogenesis, including initiation, progression, invasion, and metastasis. This chapter updates the current understanding of osteogenic osteosarcoma biology and reviews these recent findings from animal models. Osteosarcoma premalignant cells that initially acquire a mutation in different stages of osteoblast differentiation may transform or evolve into cancer stem cells (CSCs) or tumor initiating cells (TICs) through accumulation of additional genetic mutations during the tumor progression. The current challenge in application of targeted agents lies in the identification of biomarkers predictive of response/resistance and matching them with the particular histologic response of individual patients, hopefully resulting in successful translation of biology into clinical benefit.
Original language | English (US) |
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Title of host publication | Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism |
Subtitle of host publication | Eighth Edition |
Publisher | Wiley-Blackwell |
Pages | 702-710 |
Number of pages | 9 |
ISBN (Electronic) | 9781118453926 |
ISBN (Print) | 9781118453889 |
DOIs | |
State | Published - Jul 19 2013 |
Externally published | Yes |
Keywords
- Animal models
- Biomarkers
- Cancer stem cells (CSCs)
- Mutations
- Osteogenic osteosarcoma
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology