Osteosarcoma among children aged 5 years or younger: The St. Jude children's research hospital experience

Christine M. Hartford, Karen S. Wodowski, Bhaskar N. Rao, Joseph D. Khoury, Michael D. Neel, Najat C. Daw

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Osteosarcoma primarily affects adolescents. The authors reviewed the records of eight patients aged 5 years or younger (of 470 patients with osteosarcoma) treated at their institution. Tumors (seven of high grade and one of low grade) arose mostly in the appendicular skeleton; one patient had metastases. One patient with low-grade osteosarcoma survived after surgery alone. Two with active disease died of chemotherapy toxicity. The remaining five (three received chemotherapy) underwent surgery and are long-term survivors. Two who underwent hemipelvectomy or hip disarticulation would likely have undergone limb-sparing surgery today. These findings and a review of the similar cases in the literature suggest that osteosarcoma's clinical characteristics are similar among young children and older children.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - Jan 2006
Externally publishedYes


  • Osteosarcoma
  • Outcome
  • Treatment
  • Young children

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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