Outpatient continuous inotrope infusion as an adjunct to heart failure therapy in Duchenne muscular dystrophy

Linda H. Cripe, Brent J. Barber, Robert L. Spicer, Brenda L. Wong, Norbert Weidner, D. Woodrow Benson, Larry W. Markham

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We report the use of continuous intravenous inotrope infusion as a palliative management strategy for the treatment of symptomatic, refractory, end stage cardiac dysfunction in patients with Duchenne muscular dystrophy. Milrinone and/or dobutamine administered by continuous intravenous infusion provided symptomatic and objective cardiovascular improvement up to 30 months in 3 individuals with Duchenne muscular dystrophy and severe dilated cardiomyopathy. Continuous inotrope infusion should be considered a practical treatment strategy for end stage cardiac dysfunction in Duchenne muscular dystrophy patients when cardiac transplantation is not a viable option.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalNeuromuscular Disorders
Volume16
Issue number11
DOIs
StatePublished - Nov 2006

Keywords

  • Dobutamine
  • Duchenne muscular dystrophy
  • Inotropes
  • Milrinone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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