Outside the mainstream: Novel collecting duct proteins regulating water balance

Shamma S. Rahman, Erika I. Boesen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Body water balance is critical to survival and, therefore, very tightly regulated by the hypothalamus and kidney. A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis. In this Mini-Review, we briefly discuss these novel proteins and their roles in the regulation of water homeostasis.

Original languageEnglish (US)
Pages (from-to)F1341-F1345
JournalAmerican Journal of Physiology - Renal Physiology
Issue number6
StatePublished - Dec 1 2016


  • Aquaporin 2
  • Collecting duct
  • Water homeostasis

ASJC Scopus subject areas

  • Physiology
  • Urology


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