Ovarian Follicle Biology and the Basis for Gonadotoxicity

Marilia Henriques Cordeiro; So Youn Kim; Teresa K. Woodruff

doi:10.1016/B978-0-12-801591-9.00001-1

Ovarian Follicle Biology and the Basis for Gonadotoxicity

Marilia Henriques Cordeiro, So Youn Kim, Teresa K. Woodruff

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Normal ovarian function requires tight control of germ cell meiosis and the quantitative activation or loss of ovarian follicles from the primordial follicle pool over the reproductive lifespan. The mechanisms controlling the activation of specific subsets of primordial follicles during this lengthy time are complex, involving coordination of what we now understand to be multiple molecular cues. In this chapter we review ovarian follicle development from initial formation in the embryo to activation, growth and endocrine regulation during the normal reproductive lifespan. We discuss how the unique features of primordial follicle biology relate to their vulnerability to chemotherapy and radiation treatment, emphasizing the importance of preserving the ovarian reserve to ensure normal ovarian function and the endocrine health of the individual.

Original language	English (US)
Title of host publication	Cancer Treatment and the Ovary
Subtitle of host publication	Clinical and Laboratory Analysis of Ovarian Toxicity
Publisher	Elsevier Inc.
Pages	3-20
Number of pages	18
ISBN (Electronic)	9780128016015
ISBN (Print)	9780128015919
DOIs	https://doi.org/10.1016/B978-0-12-801591-9.00001-1
State	Published - Sep 1 2015
Externally published	Yes

Keywords

Endocrine system
Follicle
Follicle activation
Follicle death
Folliculogenesis
Ovarian hormones
Ovarian reserve
Ovary

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-801591-9.00001-1

Cite this

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title = "Ovarian Follicle Biology and the Basis for Gonadotoxicity",

abstract = "Normal ovarian function requires tight control of germ cell meiosis and the quantitative activation or loss of ovarian follicles from the primordial follicle pool over the reproductive lifespan. The mechanisms controlling the activation of specific subsets of primordial follicles during this lengthy time are complex, involving coordination of what we now understand to be multiple molecular cues. In this chapter we review ovarian follicle development from initial formation in the embryo to activation, growth and endocrine regulation during the normal reproductive lifespan. We discuss how the unique features of primordial follicle biology relate to their vulnerability to chemotherapy and radiation treatment, emphasizing the importance of preserving the ovarian reserve to ensure normal ovarian function and the endocrine health of the individual.",

keywords = "Endocrine system, Follicle, Follicle activation, Follicle death, Folliculogenesis, Ovarian hormones, Ovarian reserve, Ovary",

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AU - Cordeiro, Marilia Henriques

AU - Kim, So Youn

AU - Woodruff, Teresa K.

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N2 - Normal ovarian function requires tight control of germ cell meiosis and the quantitative activation or loss of ovarian follicles from the primordial follicle pool over the reproductive lifespan. The mechanisms controlling the activation of specific subsets of primordial follicles during this lengthy time are complex, involving coordination of what we now understand to be multiple molecular cues. In this chapter we review ovarian follicle development from initial formation in the embryo to activation, growth and endocrine regulation during the normal reproductive lifespan. We discuss how the unique features of primordial follicle biology relate to their vulnerability to chemotherapy and radiation treatment, emphasizing the importance of preserving the ovarian reserve to ensure normal ovarian function and the endocrine health of the individual.

AB - Normal ovarian function requires tight control of germ cell meiosis and the quantitative activation or loss of ovarian follicles from the primordial follicle pool over the reproductive lifespan. The mechanisms controlling the activation of specific subsets of primordial follicles during this lengthy time are complex, involving coordination of what we now understand to be multiple molecular cues. In this chapter we review ovarian follicle development from initial formation in the embryo to activation, growth and endocrine regulation during the normal reproductive lifespan. We discuss how the unique features of primordial follicle biology relate to their vulnerability to chemotherapy and radiation treatment, emphasizing the importance of preserving the ovarian reserve to ensure normal ovarian function and the endocrine health of the individual.

KW - Endocrine system

KW - Follicle

KW - Follicle activation

KW - Follicle death

KW - Folliculogenesis

KW - Ovarian hormones

KW - Ovarian reserve

KW - Ovary

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BT - Cancer Treatment and the Ovary

PB - Elsevier Inc.

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Ovarian Follicle Biology and the Basis for Gonadotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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