Ovarian Follicle Biology and the Basis for Gonadotoxicity

Marilia Henriques Cordeiro, So Youn Kim, Teresa K. Woodruff

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Normal ovarian function requires tight control of germ cell meiosis and the quantitative activation or loss of ovarian follicles from the primordial follicle pool over the reproductive lifespan. The mechanisms controlling the activation of specific subsets of primordial follicles during this lengthy time are complex, involving coordination of what we now understand to be multiple molecular cues. In this chapter we review ovarian follicle development from initial formation in the embryo to activation, growth and endocrine regulation during the normal reproductive lifespan. We discuss how the unique features of primordial follicle biology relate to their vulnerability to chemotherapy and radiation treatment, emphasizing the importance of preserving the ovarian reserve to ensure normal ovarian function and the endocrine health of the individual.

Original languageEnglish (US)
Title of host publicationCancer Treatment and the Ovary
Subtitle of host publicationClinical and Laboratory Analysis of Ovarian Toxicity
PublisherElsevier Inc.
Number of pages18
ISBN (Electronic)9780128016015
ISBN (Print)9780128015919
StatePublished - Sep 1 2015
Externally publishedYes


  • Endocrine system
  • Follicle
  • Follicle activation
  • Follicle death
  • Folliculogenesis
  • Ovarian hormones
  • Ovarian reserve
  • Ovary

ASJC Scopus subject areas

  • Medicine(all)


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