Overlapping demyelinating syndrome and anti-N-methyl-D-aspartate receptor encephalitis with seizures

Olga Taraschenko, Rana Zabad

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the most recognized type of autoimmune encephalitis, manifests with rapid cognitive decline, psychosis, and seizures that develop in 78–86% of patients. Recently, anti-NMDAR encephalitis was reported in association with demyelinating diseases which are accompanied by a characteristic clinical phenotype, imaging abnormalities, and the presence of antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) in bodily fluids. The patient presented herein suffered from bilateral optic neuritis followed by recurrent encephalitis with focal seizures and demonstrated anti-NMDAR and MOG-IgGs in the cerebrospinal fluid and serum, respectively. Her symptoms responded to immunotherapy and antiseizure medication. The recognition of the novel syndrome of MOG antibody-associated demyelination (MOGAD), encompassing the overlapping anti-NMDAR encephalitis and other MOG-IgG associated disorders, is important for the successful management of these patients.

Original languageEnglish (US)
Article number100338
JournalEpilepsy and Behavior Reports
StatePublished - 2019


  • Anti-NMDA receptor encephalitis
  • Autoantibodies
  • Autoimmune encephalitis
  • Demyelinating disease
  • Myelin oligodendrocyte glycoprotein
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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