Abstract
The mononuclear phagocyte (MP; monocyte, macrophages, dendritic cells and microglia) is part of innate immunity that functions by nonspecific surveillance and clearing response through phagocytic and intracellular killing activities. MPs included are present within the reticular connective tissues and accumulate in lymph nodes, spleen, liver and as histiocytes, tissue macrophages, Kupffer cells and microglia. It is estimated that there are at any time six billion MP/L of blood. MPs are divided into non-professional and professional categories based on function. Phagocytosis is a key function that phagocytes possess to survey their environment, ingest and process material. This chapter expands on the mechanisms, benefits, and uses of the mononuclear phagocyte.
| Original language | English (US) |
|---|---|
| Title of host publication | Neuroimmune Pharmacology |
| Publisher | Springer International Publishing |
| Pages | 141-153 |
| Number of pages | 13 |
| ISBN (Electronic) | 9783319440224 |
| ISBN (Print) | 9783319440200 |
| DOIs | |
| State | Published - Jan 1 2016 |
Keywords
- Antigen presentation
- Complement receptors
- Experimental allergic encephalomyelitis
- Lectin
- Mononuclear phagocyte
- Phagocytosis
- Progenitor cells
- Toll-like receptors
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology
- General Neuroscience
- Pharmacology, Toxicology and Pharmaceutics(all)