Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking

X. Shang; Y. Chen; N. Wang; W. Niu; J. Guo

doi:10.1039/c8cc01639a

Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking

X. Shang, Y. Chen, N. Wang, W. Niu, J. Guo

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile.

Original language	English (US)
Pages (from-to)	4172-4175
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	33
DOIs	https://doi.org/10.1039/c8cc01639a
State	Published - 2018

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c8cc01639a

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title = "Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking",

abstract = "We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile.",

author = "X. Shang and Y. Chen and N. Wang and W. Niu and J. Guo",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

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AU - Shang, X.

AU - Chen, Y.

AU - Wang, N.

AU - Niu, W.

AU - Guo, J.

PY - 2018

Y1 - 2018

N2 - We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile.

AB - We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile.

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DO - 10.1039/c8cc01639a

M3 - Article

C2 - 29629441

AN - SCOPUS:85045839290

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SP - 4172

EP - 4175

JO - Chemical Communications

JF - Chemical Communications

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ER -

Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking

Abstract

ASJC Scopus subject areas

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