Oxidative stress based-biomarkers in oral carcinogenesis: How far have we gone?

R. Hanafi, I. Anestopoulos, G. P. Voulgaridou, R. Franco, A. G. Georgakilas, D. Ziech, V. Malamou-Mitsi, A. Pappa, M. I. Panayiotidis

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidativemodified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.

Original languageEnglish (US)
Pages (from-to)698-703
Number of pages6
JournalCurrent Molecular Medicine
Issue number6
StatePublished - Jul 2012


  • DNA oxidation
  • Leukoplakia
  • Lichen planus
  • Lipid oxidation
  • OSCC
  • Oral carcinogenesis
  • Oxidative stress
  • Protein oxidation
  • Reactive oxygen species (ROS)
  • Submucous fibrosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology


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