Oxidative stress in Alzheimer disease: A possibility for prevention

David J. Bonda, Xinglong Wang, George Perry, Akihiko Nunomura, Massimo Tabaton, Xiongwei Zhu, Mark A. Smith

Research output: Contribution to journalReview articlepeer-review

344 Scopus citations

Abstract

Oxidative stress is at the forefront of Alzheimer disease (AD) research. While its implications in the characteristic neurodegeneration of AD are vast, the most important aspect is that it seems increasingly apparent that oxidative stress is in fact a primary progenitor of the disease, and not merely an epiphenomenon. Moreover, evidence indicates that a long " dormant period" of gradual oxidative damage accumulation precedes and actually leads to the seemingly sudden appearance of clinical and pathological AD symptoms, including amyloid-β deposition, neurofibrillary tangle formation, metabolic dysfunction, and cognitive decline. These findings provide important insights into the development of potential treatment regimens and even allude to the possibility of a preventative cure. In this review, we elaborate on the dynamic role of oxidative stress in AD and present corresponding treatment strategies that are currently under investigation.

Original languageEnglish (US)
Pages (from-to)290-294
Number of pages5
JournalNeuropharmacology
Volume59
Issue number4-5
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Alzheimer disease
  • Antioxidants
  • Coenzyme Q
  • Dimebon
  • MitoQ
  • Mitochondrial antioxidants
  • Oxidative stress
  • Reactive oxidative species

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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