Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration

Annadurai Anandhan, Pablo Hernandez-Franco, Rodrigo Franco

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

NF-κB is a multifunctional redox sensitive transcription factor. In neurodegenerative disorders such as Alzheimer's, Huntington's, Parkinson's disease and amyotrophic lateral sclerosis (ALS), inducible NF-κB activation is observed in glial cells (astrocytes and microglia) as an inflammatory response that regulates the expression of cytokines, chemokines and adhesion molecules as well as the generation of reactive oxygen (ROS) and nitrogen species (RNS). As such, NF-κB activation is thought to contribute to neuronal loss. However, there is strong evidence demonstrating that in neurons, NF-κB protects against cell death progression by regulation of anti-apoptotic genes. Understanding the molecular pathways involved in NF-κB activation during neurodegeneration and its downstream signaling mediating pro-survival, pro-death and inflammatory responses will provide novel targets for therapeutic intervention. In this chapter we revise the role of NF-κB in neurodegeneration, its role in oxidative stress and antioxidant defense in the brain, and its regulation by redox homeostasis and oxidative stress.

Original languageEnglish (US)
Title of host publicationOxidative Stress
Subtitle of host publicationDiagnostics, Prevention, and Therapy Volume 2
EditorsSilvana Andreescu, Maria Hepel
PublisherAmerican Chemical Society
Pages53-90
Number of pages38
ISBN (Electronic)9780841231009
DOIs
StatePublished - Jan 1 2015

Publication series

NameACS Symposium Series
Volume1200
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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    Anandhan, A., Hernandez-Franco, P., & Franco, R. (2015). Oxidative stress, redox homeostasis and NF-κB signaling in neurodegeneration. In S. Andreescu, & M. Hepel (Eds.), Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2 (pp. 53-90). (ACS Symposium Series; Vol. 1200). American Chemical Society. https://doi.org/10.1021/bk-2015-1200.ch003