Oxidized sucrose: A potent and biocompatible crosslinker for three-dimensional fibrous protein scaffolds

Peng Liu, Helan Xu, Xiang Mi, Lan Xu, Yiqi Yang

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Oxidized sucrose, an un-traditional biobased crosslinker, was proved as effective as glutaraldehyde in improving water stability of ultrafine fibrous proteins without causing cytotoxicity. Proteins from agricultural byproducts, such as zein, are abundantly available for production of industrial and medical products, but are restricted by their poor water stability and wet properties. An effective and safe crosslinking method became indispensable for protein-based materials, especially biomaterials. Fibrous basic units with sub-micron scale were critical for biomaterials to resemble native extracellular matrices (ECMs) structurally. In this research, sucrose was oxidized into polar polyaldehydes to crosslink ultrafine fibrous scaffolds from corn protein. The control groups were crosslinked with glutaraldehyde, a known highly effective crosslinker with considerable toxicity. With similar improvement in water stability, the oxidized sucrose crosslinked scaffolds showed much better cytocompatibility than the glutaraldehyde crosslinked ones via in vitro study with preosteoblast cells.

Original languageEnglish (US)
Pages (from-to)414-422
Number of pages9
JournalMacromolecular Materials and Engineering
Issue number4
StatePublished - Apr 1 2015


  • 3D scaffolds
  • biomedical materials
  • non-toxic crosslinking
  • oxidized sucrose
  • proteins

ASJC Scopus subject areas

  • General Chemical Engineering
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


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