Oxygen-releasing antibacterial nanofibrous scaffolds for tissue engineering applications

Turdimuhammad Abdullah, Kalamegam Gauthaman, Ahmed H. Hammad, Kasturi Joshi Navare, Ahmed A. Alshahrie, Sidi A. Bencherif, Ali Tamayol, Adnan Memic

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly("-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications.

Original languageEnglish (US)
Article number1233
Issue number6
StatePublished - Jun 1 2020


  • Antibacterial properties
  • Biocompatibility
  • Biodegradability
  • Calcium peroxide
  • Electrospinning
  • Oxygen-releasing scaffold

ASJC Scopus subject areas

  • General Chemistry
  • Polymers and Plastics


Dive into the research topics of 'Oxygen-releasing antibacterial nanofibrous scaffolds for tissue engineering applications'. Together they form a unique fingerprint.

Cite this