Abstract
Studies were performed to characterize phosphorus-31 magnetic resonance (MR) spectra obtained from 10 superficial human tumors outside the brain and to determine whether P-31 MR spectroscopy could allow detection of a response to therapy before a change in tumor size was measured. The ratio of phosphomonoester to adenosine triphosphate peak intensities (PME/ ATP) was unusually large in all tumors studied. The average PME/ ATP in lymphomas (1.8 ± 0.5) was greater than in nonlymphoma cancers (1.1 ± 0.15). The average PME/ ATP for all tumors studied (1.4 ± 0.5) was much greater than that of underlying skeletal muscle (0.23 ± .09). Eight of the tumors were studied before and after therapy. Responders were distinguished from nonresponders on the basis of changes in tumor size. PME/ATP decreased during therapy in three lymphomas that responded to therapy. In an adenocarcinoma and Ewing sarcoma that did not respond to therapy, PME/ATP increased. PME/ ATP remained constant in two squamous cell carcinomas that responded to therapy and decreased in one squamous cell carcinoma that decreased in size by 40% but was classified as a nonresponder. Changes in PME/ATP did not always parallel changes in tumor size during therapy. In two patients, a decrease in PME/ATP preceded a decrease in tumor size. In four patients, PME/ ATP increased transiently during periods when tumor size remained constant.
Original language | English (US) |
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Pages (from-to) | 149-153 |
Number of pages | 5 |
Journal | Radiology |
Volume | 179 |
Issue number | 1 |
DOIs | |
State | Published - Apr 1991 |
Externally published | Yes |
Keywords
- Head and neck neoplasms
- Lymphoma, MR studies, 99.1214
- Magnetic resonance (MR), phosphorus studies
- Magnetic resonance (MR), spectroscopy
- Magnetic resonance (MR), tissue characterization
- Magnetic resonance (MR), treatment planning
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging