P-selectin expression in a metastatic pancreatic tumor cell line (SUIT- 2)

Takeshi Iwamura, Thomas C. Caffrey, Norio Kitamura, Hideo Yamanari, Toshiaki Setoguchi, Michael A. Hollingsworth

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

The human pancreatic tumor cell line SUIT-2 was derived from a metastatic lesion in the liver of a patient with pancreatic adenocarcinoma. SUIT-2 and clonal cell lines derived from it show spontaneous metastasis to lung and regional lymph nodes from s.c. nude mouse xenografts and were found to express P-selectin mRNA and protein. Surface expression of P-selectin protein was increased by exposure of the pancreatic tumor cells to thrombin, oxygen radicals, and trypsin, suggesting that common cellular mechanisms for regulating P-selectin surface expression exist among platelets, endothelial cells, and these pancreatic tumor cells. The finding that P-selectin is expressed by metastatic pancreatic tumor cells demonstrates that the range of cell types that express these adhesion molecules is broader than believed previously.

Original languageEnglish (US)
Pages (from-to)1206-1212
Number of pages7
JournalCancer Research
Volume57
Issue number6
StatePublished - 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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