P62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress

Huabo Su, Xuejun Wang

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalTrends in Cardiovascular Medicine
Volume21
Issue number8
DOIs
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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