Paclitaxel-loaded biodegradable nanoparticles developed by direct dialysis and electrodydrodynamic atomization methods

Jingwei Xie, Chi Hwa Wang

Research output: Contribution to conferencePaper

3 Scopus citations

Abstract

This paper presents a new method for fabrication of biodegradable polymeric nanoparticles as carriers for anticancer drug paclitaxel. Emulsion solvent evaporation method was frequently employed to prepare polymeric nanoparticles for drug delivery systems in which the emulsifier such as PVA has to be used. In this study, direct dialysis was employed to fabricate paclitaxel-loaded biodegradable polymeric nanoparticles thus avoiding using emulsifier which potentially could remain on the surface of the nanoparticles and affect the biodegradability, biodistribution and drug-release behavior. The nanoparticles were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) for their morphology; laser scattering particle size analyzer for particle size distribution; and, zeta potential analyzer for their surface charge. The physical status of paclitaxel in polymer matrix by different theory drug loadings was studied by differential scanning calorimetry (DSC) and X-ray diffractometry pattern. The encapsulation efficiency and in vitro release profile were measured by high performance liquid chromatography (HPLC). C6 glioma cell line was used to evaluate the particle cellular uptake and cytotoxicity.

Original languageEnglish (US)
Pages2193-2202
Number of pages10
StatePublished - 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Conference

Conference2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

ASJC Scopus subject areas

  • Engineering(all)

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    Xie, J., & Wang, C. H. (2004). Paclitaxel-loaded biodegradable nanoparticles developed by direct dialysis and electrodydrodynamic atomization methods. 2193-2202. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.