Pan masala - a genotoxic menace

Rashmi K. Patel, Rina J. Jaju, Sonal R. Bakshi, Amit H. Trivedi, Bhavana J. Dave, Siddharth G. Adhvaryu

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Cytogenetic markers such as chromosome aberration (CA), sister-chromatid exchange (SCE) and micronucleated cells (MNC) were used to assess the genotoxic potential of dimethyl sulphoxide (DMSO) extract of pan masala with and without tobacco (PM-T and PM). Using in vitro short-term assays, the extracts were tested in the presence or absence of metabolic activation. In cultures without metabolic activation the extracts were found to increase the frequency of all the three parameters tested significantly, however those with activation elicited a weak response, implying that pan masalas contain solvent (DMSO)-soluble direct-acting mutagen.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalMutation Research/Genetic Toxicology
Volume320
Issue number3
DOIs
StatePublished - Feb 1994

Keywords

  • Chromosome aberration
  • DMSO extract
  • Metabolic activation
  • Micronucleated cells
  • Pan masala
  • Sister-chromatid exchange

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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    Patel, R. K., Jaju, R. J., Bakshi, S. R., Trivedi, A. H., Dave, B. J., & Adhvaryu, S. G. (1994). Pan masala - a genotoxic menace. Mutation Research/Genetic Toxicology, 320(3), 245-249. https://doi.org/10.1016/0165-1218(94)90051-5