Pancreas transplantation

Robert J. Stratta, Rodney J. Taylor, Jennifer L. Larsen, Kathleen Cushing

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Vascularized pancreas transplantation has assumed an increasing role in the treatment of diabetes mellitus. Through 1994, over 6000 pancreas transplants had been performed worldwide, with over 80% being combined pancreas-kidney transplants. Overall 1-year patient survival exceeds 90% and graft survival (complete insulin independence) exceeds 70% Although successful pancreas transplantation achieves euglycemia and complete insulin independence, this occurs at the expense of hyperinsulinemia and chronic immunosup-pression. The net effect of these changes on diabetic complications in the long term remains to be determined. In the short term, improvement in the quality of life and possible prevention of further morbidity associated with diabetes makes pancreas transplantation an important therapeutic option, particularly when combined with a kidney transplant, in appropriately selected diabetic patients.

Original languageEnglish (US)
Pages (from-to)323-337
Number of pages15
JournalRenal Failure
Volume17
Issue number4
DOIs
StatePublished - 1995

Keywords

  • Diabetes mellitus
  • Immunosuppression
  • Kidney transplantation
  • Pancreas transplantation
  • Pancreas-kidney transplantation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology

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