Pancreatic IL-10 induces diabetes in NOD. B6 Idd3 Idd10 mice

Myung Shik Lee; Linda S. Wicker; Laurence B. Peterson; Nora Sarvetnick

doi:10.3109/08916939709008027

Pancreatic IL-10 induces diabetes in NOD. B6 Idd3 Idd10 mice

Myung Shik Lee, Linda S. Wicker, Laurence B. Peterson, Nora Sarvetnick

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Transgenic NOD backcross mice expressing pancreatic interleukin 10 (IL-10) were crossed and backcrossed to NOD.B6 Idd3 Idd10 mice, which have diabetes-resistance alleles at Idd3 and Idd10 on chromosome 3 and have a very low frequency diabetes and insulitis. Insulitis and diabetes developed in almost all IL-10 transgenic backcross 1 (BC1) mice of the H2g(7/g7) haplotype regardless of the allelic status at Idd3 and Idd10. Furthermore, diabetes occurred in 23% of IL-10 transgenic H2(g7/d) BC1 mice. These results indicate that pancreatic IL-10 is able to overcome the diabetes protection afforded by C57BL/6 (B6)-derived alleles at Idd3 and Idd10 as well as the absence of NOD MHC homozygosity, if other non-MHC NOD-derived Idd alleles are provided.

Original language	English (US)
Pages (from-to)	215-221
Number of pages	7
Journal	Autoimmunity
Volume	26
Issue number	4
DOIs	https://doi.org/10.3109/08916939709008027
State	Published - 1997
Externally published	Yes

Keywords

Idd3 Idd10 mice
Induces diabetes
Pancreatic IL-10

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3109/08916939709008027

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title = "Pancreatic IL-10 induces diabetes in NOD. B6 Idd3 Idd10 mice",

abstract = "Transgenic NOD backcross mice expressing pancreatic interleukin 10 (IL-10) were crossed and backcrossed to NOD.B6 Idd3 Idd10 mice, which have diabetes-resistance alleles at Idd3 and Idd10 on chromosome 3 and have a very low frequency diabetes and insulitis. Insulitis and diabetes developed in almost all IL-10 transgenic backcross 1 (BC1) mice of the H2g(7/g7) haplotype regardless of the allelic status at Idd3 and Idd10. Furthermore, diabetes occurred in 23% of IL-10 transgenic H2(g7/d) BC1 mice. These results indicate that pancreatic IL-10 is able to overcome the diabetes protection afforded by C57BL/6 (B6)-derived alleles at Idd3 and Idd10 as well as the absence of NOD MHC homozygosity, if other non-MHC NOD-derived Idd alleles are provided.",

keywords = "Idd3 Idd10 mice, Induces diabetes, Pancreatic IL-10",

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doi = "10.3109/08916939709008027",

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pages = "215--221",

journal = "Autoimmunity",

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T1 - Pancreatic IL-10 induces diabetes in NOD. B6 Idd3 Idd10 mice

AU - Lee, Myung Shik

AU - Wicker, Linda S.

AU - Peterson, Laurence B.

AU - Sarvetnick, Nora

PY - 1997

Y1 - 1997

N2 - Transgenic NOD backcross mice expressing pancreatic interleukin 10 (IL-10) were crossed and backcrossed to NOD.B6 Idd3 Idd10 mice, which have diabetes-resistance alleles at Idd3 and Idd10 on chromosome 3 and have a very low frequency diabetes and insulitis. Insulitis and diabetes developed in almost all IL-10 transgenic backcross 1 (BC1) mice of the H2g(7/g7) haplotype regardless of the allelic status at Idd3 and Idd10. Furthermore, diabetes occurred in 23% of IL-10 transgenic H2(g7/d) BC1 mice. These results indicate that pancreatic IL-10 is able to overcome the diabetes protection afforded by C57BL/6 (B6)-derived alleles at Idd3 and Idd10 as well as the absence of NOD MHC homozygosity, if other non-MHC NOD-derived Idd alleles are provided.

AB - Transgenic NOD backcross mice expressing pancreatic interleukin 10 (IL-10) were crossed and backcrossed to NOD.B6 Idd3 Idd10 mice, which have diabetes-resistance alleles at Idd3 and Idd10 on chromosome 3 and have a very low frequency diabetes and insulitis. Insulitis and diabetes developed in almost all IL-10 transgenic backcross 1 (BC1) mice of the H2g(7/g7) haplotype regardless of the allelic status at Idd3 and Idd10. Furthermore, diabetes occurred in 23% of IL-10 transgenic H2(g7/d) BC1 mice. These results indicate that pancreatic IL-10 is able to overcome the diabetes protection afforded by C57BL/6 (B6)-derived alleles at Idd3 and Idd10 as well as the absence of NOD MHC homozygosity, if other non-MHC NOD-derived Idd alleles are provided.

KW - Idd3 Idd10 mice

KW - Induces diabetes

KW - Pancreatic IL-10

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JO - Autoimmunity

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Pancreatic IL-10 induces diabetes in NOD. B6 Idd3 Idd10 mice

Abstract

Keywords

ASJC Scopus subject areas

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