TY - CHAP
T1 - Pancreatic Stellate Cells
T2 - The Key Orchestrator of The Pancreatic Tumor Microenvironment
AU - Thomas, Divya
AU - Radhakrishnan, Prakash
PY - 2020
Y1 - 2020
N2 - Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile molecular behavior and complex tumor microenvironment. It has been recently postulated that pancreatic stellate cells (PSCs), the resident lipid-storing cells of the pancreas, are important components of the tumor microenvironment as they can transdifferentiate into highly proliferative myofibroblasts in the context of tissue injury. Targeting tumor-stromal crosstalk in the tumor microenvironment has emerged as a promising therapeutic strategy against pancreatic cancer progression and metastasis. This chapter brings a broad view on the biological and pathological role of PSCs in the pancreas, activated stellate cells in the onset of tissue fibrosis, and tumor progression with particular emphasis on the bidirectional interactions between tumor cells and PSCs. Further, potential therapeutic regimens targeting activated PSCs in the pre-clinical and clinical trials are discussed.
AB - Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile molecular behavior and complex tumor microenvironment. It has been recently postulated that pancreatic stellate cells (PSCs), the resident lipid-storing cells of the pancreas, are important components of the tumor microenvironment as they can transdifferentiate into highly proliferative myofibroblasts in the context of tissue injury. Targeting tumor-stromal crosstalk in the tumor microenvironment has emerged as a promising therapeutic strategy against pancreatic cancer progression and metastasis. This chapter brings a broad view on the biological and pathological role of PSCs in the pancreas, activated stellate cells in the onset of tissue fibrosis, and tumor progression with particular emphasis on the bidirectional interactions between tumor cells and PSCs. Further, potential therapeutic regimens targeting activated PSCs in the pre-clinical and clinical trials are discussed.
KW - Cancer-associated fibroblast
KW - Desmoplasia
KW - Drug resistance
KW - Fibrosis
KW - Pancreatic cancer
KW - Pancreatic stellate cells
KW - Stroma
KW - TGFβ
KW - Tumor microenvironment
KW - Wnt signaling
UR - http://www.scopus.com/inward/record.url?scp=85079220094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079220094&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-37184-5_5
DO - 10.1007/978-3-030-37184-5_5
M3 - Chapter
C2 - 32040855
AN - SCOPUS:85079220094
T3 - Advances in Experimental Medicine and Biology
SP - 57
EP - 70
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -