Pancreaticoduodenal transplantation in humans

T. E. Starzl, S. Iwatsuki, B. W. Shaw, D. A. Greene, D. H. Van Thiel, M. A. Nalesnik, J. Nusbacher, H. Diliz-Pere, T. R. Hakala

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Whole cadaveric pancreata were transplanted to the pelvic extraperitoneal location in four patients with diabetes who previously had undergone successful cadaveric renal transplantation. One graft was lost within a few hours from venous thrombosis but with patient survival. The other three are providing normal endocrine function after two and a half, 11 and 12 months. The exocrine pancreatic secretions were drained into the recipient jejunum through enteric anastomoses. Because mucosal slough of the graft and duodenum and jejunum in two patients caused a protein losing enteropathy and necessitated reoperations, we now do the pancreatic transplantation with only a blister of graft duodenum large enough for side-to-side enteroenterostomy. The spleen has been transplanted with the pancreas mainly for technical reasons, and this technique should have further trials in spite of the fact that delayed graft splenectomy became necessary in two recipients to treat graft induced hematologic complications.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalSurgery Gynecology and Obstetrics
Volume159
Issue number3
StatePublished - Oct 25 1984
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

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    Starzl, T. E., Iwatsuki, S., Shaw, B. W., Greene, D. A., Van Thiel, D. H., Nalesnik, M. A., Nusbacher, J., Diliz-Pere, H., & Hakala, T. R. (1984). Pancreaticoduodenal transplantation in humans. Surgery Gynecology and Obstetrics, 159(3), 265-272.