Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features

Bret C. Mobley, Manoj Kumar, Warren G. Sanger, Marilu Nelson, Hilary H. Nickols, Lola B. Chambless, Murat Gokden

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Summary Papillary tumor of the pineal region (PTPR) is an uncommon neoplasm with variable biologic behavior. Cytogenetic and molecular diagnostic studies are rare, yielding no definitive genetic signature. We report a case of PTPR with a multicentric presentation and unusual cytogenetic features. A 25-year-old man presented with headache, disconjugate gaze, and confusion. Mass lesions in the pineal and suprasellar regions, with identical imaging characteristics, were identified. The former extended partially into the fourth ventricle. It showed typical PTPR histology and losses of chromosomes 3, 7, 10, 14, 18, and Y with gains of chromosomes 3, 8, and 9. Seventeen months postsurgery, the patient is stable without disease progression after radiation therapy. Synchronous mass lesions at presentation and losses of chromosomes 3, 7, 14, 18, and Y are unusual features, adding to the available data and underscoring the biologic and genetic variability associated with these neoplasms.

Original languageEnglish (US)
Pages (from-to)1232-1236
Number of pages5
JournalHuman Pathology
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2015

Keywords

  • Circumventricular organs
  • Cytogenetics
  • Multifocal
  • Papillary tumor of the pineal region
  • Suprasellar

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Mobley, B. C., Kumar, M., Sanger, W. G., Nelson, M., Nickols, H. H., Chambless, L. B., & Gokden, M. (2015). Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features. Human Pathology, 46(8), 1232-1236. https://doi.org/10.1016/j.humpath.2015.04.014