Paradoxical urinary excretion of d-glucaric acid in acute viral hepatitis

Michael F. Sorrell; David A. Burnett; Dean J. Tuma; Anthony J. Barak

doi:10.1002/cpt1976203365

Paradoxical urinary excretion of d-glucaric acid in acute viral hepatitis

Michael F. Sorrell, David A. Burnett, Dean J. Tuma, Anthony J. Barak

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The urinary excretion of D-glucaric acid and the plasma clearance of antipyrine were estimated during the acute phase of viral hepatitis and again during recovery. The plasma clearance of antipyrine was impaired during the acute stage of hepatitis, while the urinary excretion of D-glucaric acid was paradoxically high. Both parameters returned to normal during recovery. These findings suggest that the use of urinary D-glucaric acid excretion as an index of microsomal enzyme induction is unreliable when there is liver injury.

Original language	English (US)
Pages (from-to)	365-368
Number of pages	4
Journal	Clinical Pharmacology and Therapeutics
Volume	20
Issue number	3
DOIs	https://doi.org/10.1002/cpt1976203365
State	Published - Sep 1976
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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abstract = "The urinary excretion of D-glucaric acid and the plasma clearance of antipyrine were estimated during the acute phase of viral hepatitis and again during recovery. The plasma clearance of antipyrine was impaired during the acute stage of hepatitis, while the urinary excretion of D-glucaric acid was paradoxically high. Both parameters returned to normal during recovery. These findings suggest that the use of urinary D-glucaric acid excretion as an index of microsomal enzyme induction is unreliable when there is liver injury.",

author = "Sorrell, {Michael F.} and Burnett, {David A.} and Tuma, {Dean J.} and Barak, {Anthony J.}",

year = "1976",

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AU - Sorrell, Michael F.

AU - Burnett, David A.

AU - Tuma, Dean J.

AU - Barak, Anthony J.

PY - 1976/9

Y1 - 1976/9

N2 - The urinary excretion of D-glucaric acid and the plasma clearance of antipyrine were estimated during the acute phase of viral hepatitis and again during recovery. The plasma clearance of antipyrine was impaired during the acute stage of hepatitis, while the urinary excretion of D-glucaric acid was paradoxically high. Both parameters returned to normal during recovery. These findings suggest that the use of urinary D-glucaric acid excretion as an index of microsomal enzyme induction is unreliable when there is liver injury.

AB - The urinary excretion of D-glucaric acid and the plasma clearance of antipyrine were estimated during the acute phase of viral hepatitis and again during recovery. The plasma clearance of antipyrine was impaired during the acute stage of hepatitis, while the urinary excretion of D-glucaric acid was paradoxically high. Both parameters returned to normal during recovery. These findings suggest that the use of urinary D-glucaric acid excretion as an index of microsomal enzyme induction is unreliable when there is liver injury.

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JO - Clinical Pharmacology and Therapeutics

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ER -

Paradoxical urinary excretion of d-glucaric acid in acute viral hepatitis

Abstract

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