PARK2, parkin

B. A. Chase, K. Markopoulou

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mutations in parkin (PARK2) are common in early-onset parkinsonism, the most common cause of autosomal recessive familial Parkinson's disease (PD), and sometimes are seen in later-onset PD. Parkin participates in extensive protein-protein interactions. It is involved in protein degradation through its ubiquitin-ligase activity and in mitochondrial function through interactions with Pink1 and DJ-1.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Pages383-386
Number of pages4
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
DOIs
StatePublished - Jan 1 2010

Keywords

  • Autosomal recessive juvenile parkinsonism (ARJP)
  • Compound heterozygotes
  • Copy-number abnormalities
  • DJ-1
  • E3-ubiquitin ligase
  • Early-onset forms of Parkinson's disease (EOPD)
  • Haploinsufficiency
  • Mitochondrial dysfunction
  • PARK2
  • Parkin
  • Parkin co-regulated gene (PACRG)
  • Parkin-associated endothelin-receptor like receptor (Pael-R)
  • Pink1
  • Proteasome
  • Psychiatric symptoms
  • RING-IBR-RING (RBR) structure
  • Synphilin

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Chase, B. A., & Markopoulou, K. (2010). PARK2, parkin. In Encyclopedia of Movement Disorders (pp. 383-386). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374105-9.00364-6