PARK8, LRRK2 (Dardarin)

B. A. Chase; K. Markopoulou

doi:10.1016/B978-0-12-374105-9.00503-7

PARK8, LRRK2 (Dardarin)

B. A. Chase, K. Markopoulou

Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

PARK8 mutations affect LRRK2 or dardarin. They are found worldwide, causing 7% of familial Parkinson's disease (PD) and are also found in sporadic PD. Clinical phenotypes are similar to idiopathic PD, though neuropathology is pleiomorphic. Dardarin has multiple protein-interaction domains that may impact different cellular pathways. Elucidating its interactions will significantly aid our understanding of PD pathogenesis.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders
Publisher	Elsevier Inc.
Pages	395-399
Number of pages	5
ISBN (Electronic)	9780123741059
ISBN (Print)	9780123741011
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00503-7
State	Published - Jan 1 2010

Keywords

Ankyrin-repeat domain
Armadillo repeat
Autophosphorylation
Autosomal dominant
COR domain
Dardarin
Diffuse Lewy body disease
Kinase
LRRK2
Leucine-rich repeat domain
Lewy body PD
Lipid rafts
Nigral degeneration
PARK8
Progressive supranuclear palsy
ROC domain
Tyrosine kinase-like (TKL) subfamily
WD40 domain

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

Access to Document

10.1016/B978-0-12-374105-9.00503-7

Cite this

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title = "PARK8, LRRK2 (Dardarin)",

abstract = "PARK8 mutations affect LRRK2 or dardarin. They are found worldwide, causing 7% of familial Parkinson's disease (PD) and are also found in sporadic PD. Clinical phenotypes are similar to idiopathic PD, though neuropathology is pleiomorphic. Dardarin has multiple protein-interaction domains that may impact different cellular pathways. Elucidating its interactions will significantly aid our understanding of PD pathogenesis.",

keywords = "Ankyrin-repeat domain, Armadillo repeat, Autophosphorylation, Autosomal dominant, COR domain, Dardarin, Diffuse Lewy body disease, Kinase, LRRK2, Leucine-rich repeat domain, Lewy body PD, Lipid rafts, Nigral degeneration, PARK8, Progressive supranuclear palsy, ROC domain, Tyrosine kinase-like (TKL) subfamily, WD40 domain",

author = "Chase, {B. A.} and K. Markopoulou",

year = "2010",

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doi = "10.1016/B978-0-12-374105-9.00503-7",

language = "English (US)",

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T1 - PARK8, LRRK2 (Dardarin)

AU - Chase, B. A.

AU - Markopoulou, K.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - PARK8 mutations affect LRRK2 or dardarin. They are found worldwide, causing 7% of familial Parkinson's disease (PD) and are also found in sporadic PD. Clinical phenotypes are similar to idiopathic PD, though neuropathology is pleiomorphic. Dardarin has multiple protein-interaction domains that may impact different cellular pathways. Elucidating its interactions will significantly aid our understanding of PD pathogenesis.

AB - PARK8 mutations affect LRRK2 or dardarin. They are found worldwide, causing 7% of familial Parkinson's disease (PD) and are also found in sporadic PD. Clinical phenotypes are similar to idiopathic PD, though neuropathology is pleiomorphic. Dardarin has multiple protein-interaction domains that may impact different cellular pathways. Elucidating its interactions will significantly aid our understanding of PD pathogenesis.

KW - Ankyrin-repeat domain

KW - Armadillo repeat

KW - Autophosphorylation

KW - Autosomal dominant

KW - COR domain

KW - Dardarin

KW - Diffuse Lewy body disease

KW - Kinase

KW - LRRK2

KW - Leucine-rich repeat domain

KW - Lewy body PD

KW - Lipid rafts

KW - Nigral degeneration

KW - PARK8

KW - Progressive supranuclear palsy

KW - ROC domain

KW - Tyrosine kinase-like (TKL) subfamily

KW - WD40 domain

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U2 - 10.1016/B978-0-12-374105-9.00503-7

DO - 10.1016/B978-0-12-374105-9.00503-7

M3 - Chapter

AN - SCOPUS:85069820353

SN - 9780123741011

SP - 395

EP - 399

BT - Encyclopedia of Movement Disorders

PB - Elsevier Inc.

ER -

PARK8, LRRK2 (Dardarin)

Abstract

Keywords

ASJC Scopus subject areas

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