Abstract
PARK8 mutations affect LRRK2 or dardarin. They are found worldwide, causing 7% of familial Parkinson's disease (PD) and are also found in sporadic PD. Clinical phenotypes are similar to idiopathic PD, though neuropathology is pleiomorphic. Dardarin has multiple protein-interaction domains that may impact different cellular pathways. Elucidating its interactions will significantly aid our understanding of PD pathogenesis.
Original language | English (US) |
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Title of host publication | Encyclopedia of Movement Disorders |
Publisher | Elsevier Inc. |
Pages | 395-399 |
Number of pages | 5 |
ISBN (Electronic) | 9780123741059 |
ISBN (Print) | 9780123741011 |
DOIs | |
State | Published - Jan 1 2010 |
Keywords
- Ankyrin-repeat domain
- Armadillo repeat
- Autophosphorylation
- Autosomal dominant
- COR domain
- Dardarin
- Diffuse Lewy body disease
- Kinase
- LRRK2
- Leucine-rich repeat domain
- Lewy body PD
- Lipid rafts
- Nigral degeneration
- PARK8
- Progressive supranuclear palsy
- ROC domain
- Tyrosine kinase-like (TKL) subfamily
- WD40 domain
ASJC Scopus subject areas
- Medicine(all)
- Neuroscience(all)