PARK8, LRRK2 (Dardarin)

B. A. Chase, K. Markopoulou

Research output: Chapter in Book/Report/Conference proceedingChapter


PARK8 mutations affect LRRK2 or dardarin. They are found worldwide, causing 7% of familial Parkinson's disease (PD) and are also found in sporadic PD. Clinical phenotypes are similar to idiopathic PD, though neuropathology is pleiomorphic. Dardarin has multiple protein-interaction domains that may impact different cellular pathways. Elucidating its interactions will significantly aid our understanding of PD pathogenesis.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Number of pages5
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
StatePublished - Jan 1 2010


  • Ankyrin-repeat domain
  • Armadillo repeat
  • Autophosphorylation
  • Autosomal dominant
  • COR domain
  • Dardarin
  • Diffuse Lewy body disease
  • Kinase
  • LRRK2
  • Leucine-rich repeat domain
  • Lewy body PD
  • Lipid rafts
  • Nigral degeneration
  • PARK8
  • Progressive supranuclear palsy
  • ROC domain
  • Tyrosine kinase-like (TKL) subfamily
  • WD40 domain

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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