Partial derepression of the isoleucine-valine enzymes during methionine starvation in Salmonella typhimurium

Angie Rizzino, Michael Mastanduno, Martin Freundlich

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Methionine starvation of methionine auxotrophs in the presence of excess branched-chain amino acids results in a partial derepression of the isoleucine and valine enzymes. Reversed-phase chromatography indicated that isoleucine, valine and leucine tRNA were altered during methionine starvation. In addition, the total tRNA isolated from cells under these conditions was undermethylated. The observed derepression may be caused by the inability of methyl-deficient tRNA's to participate adequately in normal regulatory functions.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume475
Issue number2
DOIs
StatePublished - Mar 18 1977

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Partial derepression of the isoleucine-valine enzymes during methionine starvation in Salmonella typhimurium'. Together they form a unique fingerprint.

  • Cite this