PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS

T. J. Neale; S. D. Carson; P. G. Tipping; S. R. Holdsworth

doi:10.1016/S0140-6736(88)90413-8

PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS

T. J. Neale, S. D. Carson, P. G. Tipping, S. R. Holdsworth

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117 Scopus citations

Abstract

Fibrin deposition is prominent in delayed-type hypersensitivity (DTH) reactions and is initiated by antigen-specific, T-lymphocyte-directed macrophage expression of human tissue factor (HTF). To examine the role of DTH in glomerular fibrin deposition, 10 fibrin-positive and 24 fibrin-negative biopsy specimens from patients with glomerulonephritis (GN) and samples from normal controls were studied with monoclonal antibodies against T cells, macrophages, and HTF. Fibrin-positive sections showed intense glomerular staining for HTF and significantly more T cells and macrophages than fibrin-negative specimens. All the essential elements of DTH reactions can therefore be simultaneously demonstrated within glomeruli from patients with fibrin-related GN. These findings suggest a role for cell mediated immunity in GN.

Original language	English (US)
Pages (from-to)	421-424
Number of pages	4
Journal	The Lancet
Volume	332
Issue number	8608
DOIs	https://doi.org/10.1016/S0140-6736(88)90413-8
State	Published - Aug 20 1988
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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@article{4103893f8d2f493488d045d49e2d373c,

title = "PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS",

abstract = "Fibrin deposition is prominent in delayed-type hypersensitivity (DTH) reactions and is initiated by antigen-specific, T-lymphocyte-directed macrophage expression of human tissue factor (HTF). To examine the role of DTH in glomerular fibrin deposition, 10 fibrin-positive and 24 fibrin-negative biopsy specimens from patients with glomerulonephritis (GN) and samples from normal controls were studied with monoclonal antibodies against T cells, macrophages, and HTF. Fibrin-positive sections showed intense glomerular staining for HTF and significantly more T cells and macrophages than fibrin-negative specimens. All the essential elements of DTH reactions can therefore be simultaneously demonstrated within glomeruli from patients with fibrin-related GN. These findings suggest a role for cell mediated immunity in GN.",

author = "Neale, {T. J.} and Carson, {S. D.} and Tipping, {P. G.} and Holdsworth, {S. R.}",

note = "Funding Information: This work was supported by grants from the Medical Research Council of New Zealand, the Wellington Medical Research Foundation, and the Wellington Hospital Board Trust, and was presented in part at the 24th Scientific Meeting of the Australian Society of Nephrology, Sydney, May, Funding Information: This work was supported by the Armangue Fund. Correspondence should be addressed to B. M., Department of Microbiology, University of Geneva Medical School, 9 Avenue de Champel, CH 1211 Geneva 4, Switzerland.",

year = "1988",

month = aug,

day = "20",

doi = "10.1016/S0140-6736(88)90413-8",

language = "English (US)",

volume = "332",

pages = "421--424",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "8608",

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T1 - PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS

AU - Neale, T. J.

AU - Carson, S. D.

AU - Tipping, P. G.

AU - Holdsworth, S. R.

N1 - Funding Information: This work was supported by grants from the Medical Research Council of New Zealand, the Wellington Medical Research Foundation, and the Wellington Hospital Board Trust, and was presented in part at the 24th Scientific Meeting of the Australian Society of Nephrology, Sydney, May, Funding Information: This work was supported by the Armangue Fund. Correspondence should be addressed to B. M., Department of Microbiology, University of Geneva Medical School, 9 Avenue de Champel, CH 1211 Geneva 4, Switzerland.

PY - 1988/8/20

Y1 - 1988/8/20

N2 - Fibrin deposition is prominent in delayed-type hypersensitivity (DTH) reactions and is initiated by antigen-specific, T-lymphocyte-directed macrophage expression of human tissue factor (HTF). To examine the role of DTH in glomerular fibrin deposition, 10 fibrin-positive and 24 fibrin-negative biopsy specimens from patients with glomerulonephritis (GN) and samples from normal controls were studied with monoclonal antibodies against T cells, macrophages, and HTF. Fibrin-positive sections showed intense glomerular staining for HTF and significantly more T cells and macrophages than fibrin-negative specimens. All the essential elements of DTH reactions can therefore be simultaneously demonstrated within glomeruli from patients with fibrin-related GN. These findings suggest a role for cell mediated immunity in GN.

AB - Fibrin deposition is prominent in delayed-type hypersensitivity (DTH) reactions and is initiated by antigen-specific, T-lymphocyte-directed macrophage expression of human tissue factor (HTF). To examine the role of DTH in glomerular fibrin deposition, 10 fibrin-positive and 24 fibrin-negative biopsy specimens from patients with glomerulonephritis (GN) and samples from normal controls were studied with monoclonal antibodies against T cells, macrophages, and HTF. Fibrin-positive sections showed intense glomerular staining for HTF and significantly more T cells and macrophages than fibrin-negative specimens. All the essential elements of DTH reactions can therefore be simultaneously demonstrated within glomeruli from patients with fibrin-related GN. These findings suggest a role for cell mediated immunity in GN.

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ER -

PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS

Abstract

ASJC Scopus subject areas

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