TY - JOUR
T1 - Partition of maternal glucose production between conceptus and maternal tissues in sheep
AU - Hay, W. W.
AU - Sparks, J. W.
AU - Wilkening, R. B.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1983
Y1 - 1983
N2 - Experiments were conducted in late-gestation, conscious, pregnant ewes to measure maternal glucose production and the net glucose uptake by the uterus, fetus, uteroplacenta, and nonuterine maternal tissues. Glucose concentration in the ewes varied naturally or decreased in response to fasting. Normoglycemic ewes (63.8 ± 8.7 mg/dl) had a glucose production rate of 178.7 ± 44.5 mg/min compared with a rate of 76.9 ± 20.6 mg/min for hypoglycemic ewes (34.7 ± 7.4 mg/dl). Uterine glucose uptake (56.5 ± 16.8 mg/min), fetal glucose uptake (15.7 ± 5.2 mg/min), uteroplacental glucose uptake (40.8 ± 13.4 mg/min), and nonuterine maternal glucose uptake (122.2 ± 27.7 mg/min) in the normoglycemic ewes were significantly greater than in the hypoglycemic ewes (28.7 ± 5.4, 7.5 ± 4.4, 21.2 ± 6.6, and 48.2 ± 15.2 mg/min, respectively). The fractional distribution of maternally produced glucose among nonuterine maternal tissues, the fetus, and the uteroplacenta was not altered markedly by hypoglycemia despite a 57% reduction in maternal glucose production.
AB - Experiments were conducted in late-gestation, conscious, pregnant ewes to measure maternal glucose production and the net glucose uptake by the uterus, fetus, uteroplacenta, and nonuterine maternal tissues. Glucose concentration in the ewes varied naturally or decreased in response to fasting. Normoglycemic ewes (63.8 ± 8.7 mg/dl) had a glucose production rate of 178.7 ± 44.5 mg/min compared with a rate of 76.9 ± 20.6 mg/min for hypoglycemic ewes (34.7 ± 7.4 mg/dl). Uterine glucose uptake (56.5 ± 16.8 mg/min), fetal glucose uptake (15.7 ± 5.2 mg/min), uteroplacental glucose uptake (40.8 ± 13.4 mg/min), and nonuterine maternal glucose uptake (122.2 ± 27.7 mg/min) in the normoglycemic ewes were significantly greater than in the hypoglycemic ewes (28.7 ± 5.4, 7.5 ± 4.4, 21.2 ± 6.6, and 48.2 ± 15.2 mg/min, respectively). The fractional distribution of maternally produced glucose among nonuterine maternal tissues, the fetus, and the uteroplacenta was not altered markedly by hypoglycemia despite a 57% reduction in maternal glucose production.
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U2 - 10.1152/ajpendo.1983.245.4.e347
DO - 10.1152/ajpendo.1983.245.4.e347
M3 - Article
C2 - 6624905
AN - SCOPUS:0020841774
SN - 0363-6127
VL - 8
SP - E347-E350
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
IS - 4
ER -