Past, Present, and a Glance into the Future of Multiple Myeloma Treatment

Weam Othman Elbezanti, Kishore B. Challagundla, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for future treatments.

Original languageEnglish (US)
Article number415
JournalPharmaceuticals
Volume16
Issue number3
DOIs
StatePublished - Mar 2023

Keywords

  • B-cell malignancy
  • bone marrow microenvironment
  • drug resistance
  • immunotherapies
  • multiple myeloma
  • proteasome inhibitors

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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