TY - JOUR
T1 - Patent foramen ovale
T2 - The known and the to be known
AU - Kutty, Shelby
AU - Sengupta, Partho P.
AU - Khandheria, Bijoy K.
N1 - Funding Information:
Dr. Kutty receives support from the American College of Cardiology Foundation and the American Heart Association. All other authors have stated that they have no relationships relevant to the contents of this paper to disclose.
PY - 2012/5/8
Y1 - 2012/5/8
N2 - The patent foramen ovale (PFO) is a normal interatrial communication during fetal life that persists after birth in approximately 1 of every 4 adults. PFO is a potential route for embolic transit from the systemic venous circulation to the brain. Though there is compelling circumstantial evidence implicating PFO, the precise role of PFO in the pathogenesis of cryptogenic stroke is not yet established. Several randomized trials of transcatheter PFO closure versus medical management are ongoing. Results of these trials may improve our ability to select the best treatment for individual patients. Further well-designed studies are necessary to address several unresolved issues related to PFO stroke and PFO migraine pathophysiology, and to identify the patients who would most likely benefit from PFO closure. The purpose of this review is to summarize contemporary understanding, discuss current treatments, and explore some of the knowledge gaps pertaining to the clinical significance of PFO.
AB - The patent foramen ovale (PFO) is a normal interatrial communication during fetal life that persists after birth in approximately 1 of every 4 adults. PFO is a potential route for embolic transit from the systemic venous circulation to the brain. Though there is compelling circumstantial evidence implicating PFO, the precise role of PFO in the pathogenesis of cryptogenic stroke is not yet established. Several randomized trials of transcatheter PFO closure versus medical management are ongoing. Results of these trials may improve our ability to select the best treatment for individual patients. Further well-designed studies are necessary to address several unresolved issues related to PFO stroke and PFO migraine pathophysiology, and to identify the patients who would most likely benefit from PFO closure. The purpose of this review is to summarize contemporary understanding, discuss current treatments, and explore some of the knowledge gaps pertaining to the clinical significance of PFO.
KW - congenital heart disease
KW - cryptogenic stroke
KW - migraine
KW - patent foramen ovale
UR - http://www.scopus.com/inward/record.url?scp=84860450161&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860450161&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2011.09.085
DO - 10.1016/j.jacc.2011.09.085
M3 - Review article
C2 - 22554596
AN - SCOPUS:84860450161
SN - 0735-1097
VL - 59
SP - 1665
EP - 1671
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 19
ER -