Pathogenesis of abdominal aortic aneurysm: An update and look toward the future

J. J. Grange, V. Davis, B. T. Baxter

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

To date, aneurysm research has been primarily descriptive, reiterating the complex nature of the disease process. Enhanced by the convergence of matrix biochemistry, cell biology and immunology, this work is providing important new insight into how matrix metabolism is regulated in the diseased aorta. The focus is now on the inflammatory process and its regulation of the matrix remodeling which occurs with abdominal aortic aneurysm. A family of matrix-degrading enzymes appear to have a central role in this process. As we have learned from the evolution of the treatment of other pathologic processes such as peptic ulcer disease, the most effective pharmacologic therapies are designed from a thorough understanding of the pathophysiology of the disease. We are quickly moving forward in formulating a comprehensive understanding of the various complex interactions that result in the formation of aortic aneurysm. Given the progress of the past decade, we can expect the identification of aneurysm-associated genes and clinical trials of anti-inflammatory medications and protease inhibitors as we enter the 21st century.

Original languageEnglish (US)
Pages (from-to)256-265
Number of pages10
JournalVascular
Volume5
Issue number3
DOIs
StatePublished - Jun 1997

Keywords

  • aortic aneurysm
  • collagen
  • elastin
  • inflammation
  • matrix metalloproteinase

ASJC Scopus subject areas

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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