@article{02288fad242648479dccc284774e8e74,
title = "Pathogenesis of aging and age-related comorbidities in people with HIV: Highlights from the HIV action workshop",
abstract = "People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff orga-nized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.",
keywords = "Aging, Cellular senescence, HIV, Inflammaging, Microbiome",
author = "Dana Gabuzda and Jamieson, {Beth D.} and Collman, {Ronald G.} and Lederman, {Michael M.} and Burdo, {Tricia H.} and Deeks, {Steven G.} and Dittmer, {Dirk P.} and Fox, {Howard S.} and Funderburg, {Nicholas T.} and Pahwa, {Savita G.} and Ivona Pandrea and Wilson, {Cara C.} and Hunt, {Peter W.}",
note = "Funding Information: We would like to acknowledge the National Institutes of Health (NIH), particularly the work-shop?s primary sponsors and contributors, the National Heart, Lung, and Blood Institute (NHL-BI) and the Office of AIDS Research (OAR), as well as the additional 19 NIH co-sponsors and contributors: the Fogarty International Center (FIC); the National Cancer Institute (NCI); the National Institute on Aging (NIA); the National Institute on Alcohol Abuse and Alcoholism (NIAAA); the National Institute of Allergy and Infectious Diseases (NIAID); the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); the National Institute on Drug Abuse (NIDA); the National Institute on Deafness and Other Communication Disorders (NIDCD); the National Institute of Dental and Craniofacial Research (NIDCR); the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); the National Institute of Mental Health (NIMH); the National Institute on Minority Health and Health Disparities (NIMHD); the National Institute of Neurological Disorders and Stroke (NINDS); the National Institute of Nursing Research (NINR); the National Library of Medicine (NLM); the Office of Behavioral and Social Sciences Research (OBSSR); the Office of Disease Prevention (ODP); the Office of Research Infrastructure Programs (ORIP); and the Office of Research on Women?s Health (ORWH). We would also like to acknowledge the workshop?s organizers from the NIH, Shimian Zou (NHL-BI), Natalie Tomitch (OAR), and Leia Novak (NIAID). We would also like to acknowledge Leia Novak (NIAID) and Lis Caler (OAR) for organizing and coordinating our working group as well, participating in the discussions along with the other members of our working group that rep-resented the NIH, Ronald Adkins (ORIP), Peter Perrin (NIDDK), Vasudev Rao (NIMH), May Wong (NINDS), and Shimian Zou (NHLBI). We also acknowledge Judith Campisi, Russell Tracy, and Steve Wakefield for helpful discussions, and thank Leia Novak for preparing figures and sup-porting the working group?s efforts through all stages of workshop organization and manuscript preparation. Manuscript preparation was supported in part by NIH R01 DA046203 (DG), R01AI110271 (PWH), R33-HL137063 (RGC), R01-DA044906 (RGC), R01 CA228172 (DPD), and R01HL123096 (IP). Funding Information: We would like to acknowledge the National Institutes of Health (NIH), particularly the workshop{\textquoteright}s primary sponsors and contributors, the National Heart, Lung, and Blood Institute (NHL-BI) and the Office of AIDS Research (OAR), as well as the additional 19 NIH co-sponsors and contributors: the Fogarty International Center (FIC); the National Cancer Institute (NCI); the National Institute on Aging (NIA); the National Institute on Alcohol Abuse and Alcoholism (NIAAA); the National Institute of Allergy and Infectious Diseases (NIAID); the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); the National Institute on Drug Abuse (NIDA); the National Institute on Deafness and Other Communication Disorders (NIDCD); the National Institute of Dental and Craniofacial Research (NIDCR); the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); the National Institute of Mental Health (NIMH); the National Institute on Minority Health and Health Disparities (NIMHD); the National Institute of Neurological Disorders and Stroke (NINDS); the National Institute of Nursing Research (NINR); the National Library of Medicine (NLM); the Office of Behavioral and Social Sciences Research (OBSSR); the Office of Disease Prevention (ODP); the Office of Research Infrastructure Programs (ORIP); and the Office of Research on Women{\textquoteright}s Health (ORWH). Funding Information: Manuscript preparation was supported in part by NIH R01 DA046203 (DG), R01AI110271 (PWH), R33-HL137063 (RGC), R01-DA044906 (RGC), R01 CA228172 (DPD), and R01HL123096 (IP). Publisher Copyright: {\textcopyright} 2020 Pathogens and Immunity.",
year = "2020",
doi = "10.20411/pai.v5i1.365",
language = "English (US)",
volume = "5",
pages = "143--174",
journal = "Pathogens and Immunity",
issn = "2469-2964",
publisher = "Case Western Reserve University",
number = "1",
}