Pathogenesis of aging and age-related comorbidities in people with HIV: Highlights from the HIV action workshop

Dana Gabuzda, Beth D. Jamieson, Ronald G. Collman, Michael M. Lederman, Tricia H. Burdo, Steven G. Deeks, Dirk P. Dittmer, Howard S. Fox, Nicholas T. Funderburg, Savita G. Pahwa, Ivona Pandrea, Cara C. Wilson, Peter W. Hunt

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff orga-nized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.

Original languageEnglish (US)
Pages (from-to)143-174
Number of pages32
JournalPathogens and Immunity
Issue number1
StatePublished - 2020


  • Aging
  • Cellular senescence
  • HIV
  • Inflammaging
  • Microbiome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Biology
  • Microbiology (medical)
  • Infectious Diseases


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