@article{02288fad242648479dccc284774e8e74,
title = "Pathogenesis of aging and age-related comorbidities in people with HIV: Highlights from the HIV action workshop",
abstract = "People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff orga-nized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.",
keywords = "Aging, Cellular senescence, HIV, Inflammaging, Microbiome",
author = "Dana Gabuzda and Jamieson, {Beth D.} and Collman, {Ronald G.} and Lederman, {Michael M.} and Burdo, {Tricia H.} and Deeks, {Steven G.} and Dittmer, {Dirk P.} and Fox, {Howard S.} and Funderburg, {Nicholas T.} and Pahwa, {Savita G.} and Ivona Pandrea and Wilson, {Cara C.} and Hunt, {Peter W.}",
note = "Funding Information: We would like to acknowledge the National Institutes of Health (NIH), particularly the workshop{\textquoteright}s primary sponsors and contributors, the National Heart, Lung, and Blood Institute (NHL-BI) and the Office of AIDS Research (OAR), as well as the additional 19 NIH co-sponsors and contributors: the Fogarty International Center (FIC); the National Cancer Institute (NCI); the National Institute on Aging (NIA); the National Institute on Alcohol Abuse and Alcoholism (NIAAA); the National Institute of Allergy and Infectious Diseases (NIAID); the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); the National Institute on Drug Abuse (NIDA); the National Institute on Deafness and Other Communication Disorders (NIDCD); the National Institute of Dental and Craniofacial Research (NIDCR); the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); the National Institute of Mental Health (NIMH); the National Institute on Minority Health and Health Disparities (NIMHD); the National Institute of Neurological Disorders and Stroke (NINDS); the National Institute of Nursing Research (NINR); the National Library of Medicine (NLM); the Office of Behavioral and Social Sciences Research (OBSSR); the Office of Disease Prevention (ODP); the Office of Research Infrastructure Programs (ORIP); and the Office of Research on Women{\textquoteright}s Health (ORWH). Funding Information: Manuscript preparation was supported in part by NIH R01 DA046203 (DG), R01AI110271 (PWH), R33-HL137063 (RGC), R01-DA044906 (RGC), R01 CA228172 (DPD), and R01HL123096 (IP).",
year = "2020",
doi = "10.20411/pai.v5i1.365",
language = "English (US)",
volume = "5",
pages = "143--174",
journal = "Pathogens and Immunity",
issn = "2469-2964",
publisher = "Case Western Reserve University",
number = "1",
}