Pathogenesis of Alcohol-Associated Liver Disease

Natalia A. Osna, Karuna Rasineni, Murali Ganesan, Terrence M. Donohue, Kusum K. Kharbanda

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Excessive alcohol consumption is a global healthcare problem with enormous social, economic, and clinical consequences. While chronic, heavy alcohol consumption causes structural damage and/or disrupts normal organ function in virtually every tissue of the body, the liver sustains the greatest damage. This is primarily because the liver is the first to see alcohol absorbed from the gastrointestinal tract via the portal circulation and second, because the liver is the principal site of ethanol metabolism. Alcohol-induced damage remains one of the most prevalent disorders of the liver and a leading cause of death or transplantation from liver disease. Despite extensive research on the pathophysiology of this disease, there are still no targeted therapies available. Given the multifactorial mechanisms for alcohol-associated liver disease pathogenesis, it is conceivable that a multitherapeutic regimen is needed to treat different stages in the spectrum of this disease.

Original languageEnglish (US)
Pages (from-to)1492-1513
Number of pages22
JournalJournal of Clinical and Experimental Hepatology
Issue number6
StatePublished - Nov 1 2022


  • alcohol
  • alcohol-associated liver disease
  • ethanol metabolism
  • liver

ASJC Scopus subject areas

  • Hepatology


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