Pathogenesis of rheumatoid arthritis: Role of B lymphocytes

Zhixin Zhang, S. Louis Bridges

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Despite many years of investigation, there remain many unanswered fundamental questions on the role of B cells in RA. Why is RF found in the sera of 80% of patients with RA and often in other chronic inflammatory diseases? What signals lead B lymphocytes to migrate into the subsynovial lining of joints? Does receptor revision in synovium play a role in the generation of autoantibodies in RA? What is the relative contribution of B-cell inhibition on the salutary effect of medications for RA? Can targeting autoreactive B cells, in conjunction with other therapies, provide therapeutic benefit in RA? We are hopeful that through continued basic, clinical, and translational research, these questions can be answered.

Original languageEnglish (US)
Pages (from-to)335-353
Number of pages19
JournalRheumatic Disease Clinics of North America
Volume27
Issue number2
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Rheumatology

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