TY - JOUR
T1 - Pathogenesis of rheumatoid arthritis
T2 - Role of B lymphocytes
AU - Zhang, Zhixin
AU - Bridges, S. Louis
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Despite many years of investigation, there remain many unanswered fundamental questions on the role of B cells in RA. Why is RF found in the sera of 80% of patients with RA and often in other chronic inflammatory diseases? What signals lead B lymphocytes to migrate into the subsynovial lining of joints? Does receptor revision in synovium play a role in the generation of autoantibodies in RA? What is the relative contribution of B-cell inhibition on the salutary effect of medications for RA? Can targeting autoreactive B cells, in conjunction with other therapies, provide therapeutic benefit in RA? We are hopeful that through continued basic, clinical, and translational research, these questions can be answered.
AB - Despite many years of investigation, there remain many unanswered fundamental questions on the role of B cells in RA. Why is RF found in the sera of 80% of patients with RA and often in other chronic inflammatory diseases? What signals lead B lymphocytes to migrate into the subsynovial lining of joints? Does receptor revision in synovium play a role in the generation of autoantibodies in RA? What is the relative contribution of B-cell inhibition on the salutary effect of medications for RA? Can targeting autoreactive B cells, in conjunction with other therapies, provide therapeutic benefit in RA? We are hopeful that through continued basic, clinical, and translational research, these questions can be answered.
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U2 - 10.1016/S0889-857X(05)70205-2
DO - 10.1016/S0889-857X(05)70205-2
M3 - Article
C2 - 11396096
AN - SCOPUS:0035001641
VL - 27
SP - 335
EP - 353
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
SN - 0889-857X
IS - 2
ER -