Pathogenesis of tuberculosis caused by Mycobacterium bovis

Charles O. Thoen, Raúl G. Barletta

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Mycobacterium bovis, the etiologic agent of bovine tuberculosis, is a slow-growing nonphotochromogenic acid-fast bacillus. In human monocyte-derived dendritic cells and macrophages, the M. tuberculosis and M. leprae microorganisms transfer into phagolysosomes prior to translocation into the cytoplasm early in infection. Pathogenicity of mycobacteria is a multifactorial phenomenon requiring the participation and cumulative effects of several virulence factors, including complex lipids and proteins in both the cell wall and the cytoplasm of tubercle bacilli. Innate immunity is the first response to mycobacterial infections and is a preparatory step for adaptive immunity. Secretion of interleukin (IL)-12, IL-18, and tumor necrosis factor alpha by antigen-presenting cells (APCs) triggers the proinflammatory response with the activation of effector cells including NK that are cytotoxic, and gamma-delta T cells that are involved in granuloma formation.

Original languageEnglish (US)
Title of host publicationZoonotic Tuberculosis
Subtitle of host publicationMycobacterium bovis and Other Pathogenic Mycobacteria: 3rd Edition
PublisherWiley-Blackwell
Pages51-62
Number of pages12
ISBN (Electronic)9781118474310
ISBN (Print)9781118474297
DOIs
StatePublished - May 5 2014

Keywords

  • Antigen-presenting cells (APCs)
  • Mycobacterial infections
  • Mycobacterial virulence
  • Mycobacterium bovis
  • Phagocytic cells
  • Tuberculosis

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Thoen, C. O., & Barletta, R. G. (2014). Pathogenesis of tuberculosis caused by Mycobacterium bovis. In Zoonotic Tuberculosis: Mycobacterium bovis and Other Pathogenic Mycobacteria: 3rd Edition (pp. 51-62). Wiley-Blackwell. https://doi.org/10.1002/9781118474310.ch5