Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets

Rodney A. Moxley, Emil M. Berberov, David H. Francis, Jun Xing, Mahtab Moayeri, Rodney A. Welch, Diane R. Baker, Raúl G. Barletta

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

Original languageEnglish (US)
Pages (from-to)5031-5035
Number of pages5
JournalInfection and immunity
Volume66
Issue number10
StatePublished - 1998

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Moxley, R. A., Berberov, E. M., Francis, D. H., Xing, J., Moayeri, M., Welch, R. A., Baker, D. R., & Barletta, R. G. (1998). Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets. Infection and immunity, 66(10), 5031-5035.