Pathological effects of lacrimal keratoconjunctivitis on the ocular surface

Steven Yeh; Stephen C. Pflugfelder; Michael E. Stern

Pathological effects of lacrimal keratoconjunctivitis on the ocular surface

Steven Yeh, Stephen C. Pflugfelder, Michael E. Stern

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Dysfunction of the lacrimal functional unit has adverse consequences for the ocular surface. Although the cause of the ocular surface pathology accompanying tear secretory dysfunction is not completely understood, it appears to be due in large part to compositional changes in the tear fluid. These include decreased concentrations of growth factors and anti-inflammatory factors, and increased concentrations of pro-inflammatory cytokines that originate from diseased lacrimal glands (as in Sjögren’s syndrome), meibomian glands (as in rosacea) and ocular surface epithelia [1,2].

Original language	English (US)
Title of host publication	Dry Eye and Ocular Surface Disorders
Publisher	CRC Press
Pages	191-203
Number of pages	13
ISBN (Electronic)	9780849378201
ISBN (Print)	9780824747022
State	Published - Jan 1 2004
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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N2 - Dysfunction of the lacrimal functional unit has adverse consequences for the ocular surface. Although the cause of the ocular surface pathology accompanying tear secretory dysfunction is not completely understood, it appears to be due in large part to compositional changes in the tear fluid. These include decreased concentrations of growth factors and anti-inflammatory factors, and increased concentrations of pro-inflammatory cytokines that originate from diseased lacrimal glands (as in Sjögren’s syndrome), meibomian glands (as in rosacea) and ocular surface epithelia [1,2].

AB - Dysfunction of the lacrimal functional unit has adverse consequences for the ocular surface. Although the cause of the ocular surface pathology accompanying tear secretory dysfunction is not completely understood, it appears to be due in large part to compositional changes in the tear fluid. These include decreased concentrations of growth factors and anti-inflammatory factors, and increased concentrations of pro-inflammatory cytokines that originate from diseased lacrimal glands (as in Sjögren’s syndrome), meibomian glands (as in rosacea) and ocular surface epithelia [1,2].

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M3 - Chapter

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PB - CRC Press

ER -

Pathological effects of lacrimal keratoconjunctivitis on the ocular surface

Abstract

ASJC Scopus subject areas

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