Abstract
Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 475-486 |
| Number of pages | 12 |
| Journal | Endocrinology and Metabolism Clinics of North America |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2012 |
Keywords
- Bone quality
- Mechanical loading
- Microdamage
- Osteoporosis
- Remodeling
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Cite this
Armas, L. A. G., & Recker, R. R. (2012). Pathophysiology of Osteoporosis. New Mechanistic Insights. Endocrinology and Metabolism Clinics of North America, 41(3), 475-486. https://doi.org/10.1016/j.ecl.2012.04.006