TY - JOUR
T1 - Patient preferences for heart failure treatment
T2 - Utilities are valid measures of health-related quality of life in heart failure
AU - Havranek, Edward P.
AU - Mcgovern, Karen M.
AU - Weinberger, Jennifer
AU - Brocato, Anthony
AU - Lowes, Brian D.
AU - Abraham, William T.
PY - 1999/6
Y1 - 1999/6
N2 - Background: Current standards hold that cost-effectiveness analyses should incorporate measures of both quantity and quality of life, and that quality of life in this context is best measured by a utility. We sought to measure utility scores for patients with heart failure and to assess their validity as measures of health-related quality of life (HRQL). Methods and Results: We studied 50 patients with heart failure. We measured utilities with the time trade-off technique, exercise capacity with a 6-minute walk test, and HRQL with the Minnesota Living With Heart Failure questionnaire, the Medical Outcomes Study Short Form-36 (SF-36) questionnaire, and a visual analogue score. Validity was assessed by establishing correlation between utilities and these other measures. Mean utility score was 0.77 ± 0.28. There were significant (P < .05) curvilinear relationships between utility score and visual analogue score, the physical function summary scale of the SF-36, 6-minute walk distance, and the Living With Heart Failure score. Utility scores on retest at I week were unchanged in a subset of 12 patients. Utilities did not vary systematically with age, sex, or ethnicity. Conclusion: Utilities are valid measures of HRQL in patients with heart failure, and cost-effectiveness analyses of heart failure treatments incorporating utilities in the outcome measure can be meaningful.
AB - Background: Current standards hold that cost-effectiveness analyses should incorporate measures of both quantity and quality of life, and that quality of life in this context is best measured by a utility. We sought to measure utility scores for patients with heart failure and to assess their validity as measures of health-related quality of life (HRQL). Methods and Results: We studied 50 patients with heart failure. We measured utilities with the time trade-off technique, exercise capacity with a 6-minute walk test, and HRQL with the Minnesota Living With Heart Failure questionnaire, the Medical Outcomes Study Short Form-36 (SF-36) questionnaire, and a visual analogue score. Validity was assessed by establishing correlation between utilities and these other measures. Mean utility score was 0.77 ± 0.28. There were significant (P < .05) curvilinear relationships between utility score and visual analogue score, the physical function summary scale of the SF-36, 6-minute walk distance, and the Living With Heart Failure score. Utility scores on retest at I week were unchanged in a subset of 12 patients. Utilities did not vary systematically with age, sex, or ethnicity. Conclusion: Utilities are valid measures of HRQL in patients with heart failure, and cost-effectiveness analyses of heart failure treatments incorporating utilities in the outcome measure can be meaningful.
KW - Cost effectiveness analyses
KW - Heart failure
KW - Quality of life
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U2 - 10.1016/S1071-9164(99)90030-1
DO - 10.1016/S1071-9164(99)90030-1
M3 - Article
C2 - 10404347
AN - SCOPUS:0033065385
SN - 1071-9164
VL - 5
SP - 85
EP - 91
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 2
ER -