Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds

Negar Faramarzi, Iman K. Yazdi, Mahboubeh Nabavinia, Andrea Gemma, Adele Fanelli, Andrea Caizzone, Leon M. Ptaszek, Indranil Sinha, Ali Khademhosseini, Jeremy N. Ruskin, Ali Tamayol

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. Platelet-rich plasma (PRP) is used as a patient-specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs. PRP contains a cocktail of growth factors enhancing angiogenesis, stem cell recruitment, and tissue regeneration. Here, the development of an alginate-based bioink that can be printed and crosslinked upon implantation through exposure to native calcium ions is reported. This platform can be used for the controlled release of PRP-associated growth factors which may ultimately enhance vascularization and stem cell migration.

Original languageEnglish (US)
Article number1701347
JournalAdvanced Healthcare Materials
Volume7
Issue number11
DOIs
StatePublished - Jun 6 2018

Keywords

  • 3D bioprinting
  • alginate-based hydrogels
  • patient-specific bioinks
  • platelet-rich plasma (PRP)
  • tissue engineering

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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    Faramarzi, N., Yazdi, I. K., Nabavinia, M., Gemma, A., Fanelli, A., Caizzone, A., Ptaszek, L. M., Sinha, I., Khademhosseini, A., Ruskin, J. N., & Tamayol, A. (2018). Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds. Advanced Healthcare Materials, 7(11), [1701347]. https://doi.org/10.1002/adhm.201701347