Abstract
Aim: Hepatocellular carcinoma (HCC) is increasing worldwide, and is frequently attributed to rising rates of hepatitis C virus infection and interactions between viral and environmental risk factors. Because of Egypt's unique risk factor profile, we analyzed data from the Gharbiah Population-Based Cancer Registry for the period 1999-2003 to characterize demographic and geographic patterns of cases in this province. Methods: We calculated age- and sex-specific and age- and sex-standardized HCC incidence rates for the eight districts in Gharbiah. We also compared rates from Gharbiah with the USA (US Surveillance Epidemiology and End Results [SEER]database). Results: The analysis revealed a higher incidence in males than in females, significant geographic variations among districts, and a higher incidence in Gharbiah than that reported by SEER. Conclusion: The findings of this study document the heterogeneous distribution of HCC at regional and international levels. This population-based registry offers the opportunity for careful representative studies of various etiologies, particularly infectious and/or environmental factors that may contribute to risk.
Original language | English (US) |
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Pages (from-to) | 465-473 |
Number of pages | 9 |
Journal | Hepatology Research |
Volume | 38 |
Issue number | 5 |
DOIs | |
State | Published - May 2008 |
Keywords
- Age-specific rates
- Developing countries
- Geographic variation
- Liver cancer
- USA
ASJC Scopus subject areas
- Hepatology
- Infectious Diseases