Patterns of hepatocellular carcinoma incidence in Egypt from a population-based cancer registry

Elizabeth M. Lehman, Amr S. Soliman, Kadry Ismail, Ahmed Hablas, Ibrahim A. Seifeldin, Mohamed Ramadan, Hesham El-Hamzawy, Christiana S. Shoushtari, Mark L. Wilson

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Aim: Hepatocellular carcinoma (HCC) is increasing worldwide, and is frequently attributed to rising rates of hepatitis C virus infection and interactions between viral and environmental risk factors. Because of Egypt's unique risk factor profile, we analyzed data from the Gharbiah Population-Based Cancer Registry for the period 1999-2003 to characterize demographic and geographic patterns of cases in this province. Methods: We calculated age- and sex-specific and age- and sex-standardized HCC incidence rates for the eight districts in Gharbiah. We also compared rates from Gharbiah with the USA (US Surveillance Epidemiology and End Results [SEER]database). Results: The analysis revealed a higher incidence in males than in females, significant geographic variations among districts, and a higher incidence in Gharbiah than that reported by SEER. Conclusion: The findings of this study document the heterogeneous distribution of HCC at regional and international levels. This population-based registry offers the opportunity for careful representative studies of various etiologies, particularly infectious and/or environmental factors that may contribute to risk.

Original languageEnglish (US)
Pages (from-to)465-473
Number of pages9
JournalHepatology Research
Volume38
Issue number5
DOIs
StatePublished - May 1 2008

Keywords

  • Age-specific rates
  • Developing countries
  • Geographic variation
  • Liver cancer
  • USA

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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    Lehman, E. M., Soliman, A. S., Ismail, K., Hablas, A., Seifeldin, I. A., Ramadan, M., El-Hamzawy, H., Shoushtari, C. S., & Wilson, M. L. (2008). Patterns of hepatocellular carcinoma incidence in Egypt from a population-based cancer registry. Hepatology Research, 38(5), 465-473. https://doi.org/10.1111/j.1872-034X.2007.00299.x