PDE4: A novel target in the treatment of chronic obstructive pulmonary disease

J. M. Michalski, G. Golden, J. Ikari, S. I. Rennard

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

Phosphodiesterases (PDEs) are important modulators of inflammation and wound healing. In this capacity, specific targeting of PDEs for the treatment of many diseases, including chronic obstructive pulmonary disease (COPD), has been investigated. Currently, treatment of COPD is suboptimal. PDE4 modulates the inflammatory response of the lung, and inhibition of PDE4 may be a novel, COPD-specific approach toward more effective treatment strategies. This review describes the state of PDE4-inhibitor therapy for use in COPD treatment.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume91
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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