TY - JOUR
T1 - Peanut oil is not allergenic to peanut-sensitive individuals
AU - Taylor, Steve L.
AU - Busse, William W.
AU - Sachs, Martin I.
AU - Parker, J. L.
AU - Yunginger, John W.
N1 - Funding Information:
From the Food Research Institute, Department of Food Mi-crobiology and Toxicology and Department of Food Science, and the Allergy Section, Department of Medicine, University of Wisconsin, Madison; and Department of Pediatrics and the Al-lergic Diseases Research Laboratory, Mayo Graduate School of Medicine, Mayo Clinic and Foundation, Rochester, Minn. Supported in part by contributions from the food industry, by the College of Agricultural and Life Sciences, University of Wis-consin, by grants from the National Institutes of Health (AI-11483 and RR-585), and by the Mayo Foundation. Dr. Busse is a recipient of an Allergic Diseases Academic Award (AI-00343) from the National Institutes of Health. Received for publication April 22, 1981. Accepted for publication July 3 1, 198 1. Reprint requests to: Steve L. Taylor, Ph.D., Food Research Insti-tute, University of Wisconsin, Madison, WI 53706.
PY - 1981/11
Y1 - 1981/11
N2 - Ten peanut-sensitive patients were enrolled in a double-blind crossover trial to determine whether ingestion of peanut oil can induce adverse reactions in such individuals. All patients had experienced prior allergic reactions to peanut ingestion, including any of the following: generalized urticaria, angioedema, abdominal cramps, vomiting, diarrhea, bronchospasm, or shock. All patients had elevated levels of serum IgE antibodies to both crude peanut extract and the purified peanut allergen, Peanut-I, by RAST assay; binding values ranged from 2 to 26 times that of negative control serum. All patients demonstrated negative puncture skin tests to both peanut oil and olive oil (control). At 30-min intervals, patients ingested 1, 2, and 5 m/ of either oil contained in 1 m/ capsules while under constant observation. These quantities exceed the maximum estimated dose of peanut oil that would occur in single meals. Patients returned 2 wk later for ingestion challenge with the remaining oil. No untoward reactions were observed with either peanut oil or olive oil. Peanut oil ingestion does not pose a risk to peanut-sensitive individuals.
AB - Ten peanut-sensitive patients were enrolled in a double-blind crossover trial to determine whether ingestion of peanut oil can induce adverse reactions in such individuals. All patients had experienced prior allergic reactions to peanut ingestion, including any of the following: generalized urticaria, angioedema, abdominal cramps, vomiting, diarrhea, bronchospasm, or shock. All patients had elevated levels of serum IgE antibodies to both crude peanut extract and the purified peanut allergen, Peanut-I, by RAST assay; binding values ranged from 2 to 26 times that of negative control serum. All patients demonstrated negative puncture skin tests to both peanut oil and olive oil (control). At 30-min intervals, patients ingested 1, 2, and 5 m/ of either oil contained in 1 m/ capsules while under constant observation. These quantities exceed the maximum estimated dose of peanut oil that would occur in single meals. Patients returned 2 wk later for ingestion challenge with the remaining oil. No untoward reactions were observed with either peanut oil or olive oil. Peanut oil ingestion does not pose a risk to peanut-sensitive individuals.
UR - http://www.scopus.com/inward/record.url?scp=0019816714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019816714&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(81)90135-4
DO - 10.1016/0091-6749(81)90135-4
M3 - Article
C2 - 7299001
AN - SCOPUS:0019816714
SN - 0091-6749
VL - 68
SP - 372
EP - 375
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 5
ER -